of TauroLock™ lock solutions
- TauroLock™ has proven effective against a wide range of bacteria and fungi (including MRSA and VRE).
- TauroLock™ is not an antibiotic – no bacterial resistance has been observed.
- TauroLock™ prevents the colonisation of catheters at the planktonic level as well as the development of biofilms within catheters.
“In vitro, the antimicrobial agent taurolidine inhibited virtually all of the bacteria tested, including vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and Stenotrophomonas maltophilia, at concentrations between 250 and 2,000 mg/ml. Taurolidine was not effective in experimental endocarditis. While it appears unlikely that this antimicrobial would be useful for systemic therapy, its bactericidal activity and the resistance rates found (<10-9) are favorable indicators for its possible development for topical use.”
“…In this study, repeated episodes of acute catheter thrombosis that required catheter removal were encountered only in the Taurolock/Hep group, with no removed catheters for the same reason from the Taurolock/U group. Furthermore, a greater anticoagulant benefit of Taurolock/U was evidenced by a significantly lower number of rt-PA interventions to restore catheter patency in this group….On estimation of the possible impact of the catheter lock solution on dialysis adequacy, Kt/V values were found to be uniformly higher in the Taurolock/U group than in the Taurolock/ Hep group, a finding that further confirms better catheter performance in Taurolock/U group.…It was found that mean BFR was significantly higher in the Taurolock/U group than in the Taurolock/Hep group at many of the measured time points, a finding that adds further evidence of better tunneled catheter performance with Taurolock/U lock solution, most probably due to its higher anti-thrombotic benefit…”