Lock solutions in dialysis
In dialysis, central venous access is needed for blood flow.
Accordingly, lock solutions must meet the following requirements:
TauroLock™ lock solutions have both strong antimicrobial and anticoagulant (or thrombolytic) properties. This prevents the formation of a biofilm. Our products comply with the recommendations of the current guidelines in terms of their efficacy and safety (ERBP, Hygiene Guideline, KDOQI, FDA).
In dialysis, the following is used predominantly:
TauroLock™
TauroLock™ is a bactericidal and fungicidal lock-solution containing the antimicrobial ingredient (cyclo)-taurolidine and the anticoagulant citrate (4%). It prevents catheter complications (infections and occlusions) reliably. Those patients who are prone to develop a higher occlusion rate will be able to use 500 IU/mL heparin (TauroLock™-Hep500) or 25000 IU Urokinase (TauroLock-U25.000). ... read more
TauroLock™-Hep500
TauroLock™-Hep500 is a bactericidal and fungicidal lock solution which contains the antimicrobial ingredient (cyclo)-taurolidine and as anticoagulant agents citrate (4%) and 500 IU/ml of heparin. Catheter complications (occlusions and infections) are reliably prevented. Occlusion rates are comparable to 5.000 IU/mL of heparin (Solomon et al., 2012).... read more
TauroLock™-U25.000
TauroLock™-U25.000 is a bactericidal and fungicidal lock solution which contains the antimicrobial ingredient (cyclo)-taurolidine and the anticoagulant agent citrate (4%) and in addition a thrombolytic agent urokinase (25.000 IU). This ensures a high flow rate. When regularly used as prophylaxis (e.g. weekly) catheter occlusions will be reliably prevented and an improved patency will simultaneously be provided.... read more
Protocol for the Use of TauroLock™-Hep500/TauroLock™-U25.000 in Hemodialysis
The CVCs of patients with high clotting rates (the so-called clotters) should be locked according to the “2+1 Protocol” as follows:... read moreThe TauroLock™ catheter lock system has been approved in Europe since 2004. All products bear the CE mark and are approved exclusively as class III medical devices. Studies have been conducted throughout the world since 2004.
The following is a list of the most important publications.
... read more