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TauroLock™-HEP100

Depending on the patient’s needs, we offer a range of specialised catheter lock solutions. TauroLock™-Hep100 is the right option for those who have previously benefited from heparin as an anti-occlusive agent.

Taurolock-Hep100-3ml

Indication and effect

TauroLock™-Hep100 has been approved for instillation in all central-venous access systems. This lock solution prevents the formation of a bacterial biofilm and thereby protects patients from catheter-related infections. At the same time, it ensures a high patency rate. We recommend TauroLock™-HEP100 for CVCs in oncology and parenteral nutrition.

Composition

TauroLock™-Hep100 contains three active ingredients:

 

  • taurolidine
  • heparin (100 units per ml)
  • citrate (4 %)

 

Taurolidine has a broad antimicrobial activity (incl. MRSA and VRE) against gram-positive and gram-negative bacteria and fungi (e.g. Candida). Heparin and citrate both help to prevent occlusions within the catheter.

Application

In-between treatment sessions, TauroLock™-Hep100 is instilled into the saline-flushed access system. Please note that medical staff must check the filling volume of the respective catheter or port system.

Expert recommendations

 

Taurolidine-based lock solutions such as TauroLock™-HEP100 are recommended in national and international guidelines. For patients suffering from heparin-induced thrombocytopenia (HIT), we offer two heparin-free alternatives:

 

Taurolock-Gmbh-Product-Hep100-With-Package

Contraindications

Patients diagnosed with HIT should not use TauroLock™-Hep100 for their vascular access system (VAD). Instead, we recommend TauroLock™ and/ or TauroLock™-U25.000. Furthermore, TauroLock™ is not suitable if:

 

  • patients have displayed a hypersensitive reaction to citrate or taurolidine
  • patients are taking medication which interferes with either citrate, heparin, or taurolidine.

Safety

TauroLockTM-HEP100 must be aspirated before the next treatment. 

Package sizes

Our customers may obtain TauroLock™-Hep100 in ampoules of 3 ml (single dose, 10 ampoules per box).

Storage & transport

TauroLock™-Hep100 must be stored at 15 °C to 30 °C. Please note that you must not freeze TauroLock™-Hep100 under any circumstances.

More information about TauroLock™-HEP100

 

For national guideline recommendations, e.g. GPOH 2018:

“Lock solutions containing taurolidine are recommended for the prevention of CVAD-associated infections.”

Download GPOH recommendations for TauroLock™-HEP100 in oncology

21.4 Taurolidine for the Prophylaxis against CVAD-related Infection

Lock solutions containing Taurolidine are recommended for the prevention of CVAD-associated Infections (scientific evidence Cat. IB, problem: reimbursement in outpatient care).

Taurolidine containing lock solutions are also recommended for paediatric-oncologic patients on cyclized (home-)parenteral nutrition if an infusion-free interval of at least 4 hours is available (Cat. IB for patients on home-parenteral nutrition).

23.6.3 Taurolidine-Lock for adjuvant therapy

Taurolidine (e.g. 1.35% Taurolidine, 4% Citrate) can be used as adjuvant measure during systemic treatment with antibiotics (Cat. II). The minimal dwell time in the catheter lumen is 4 hours.

Download study by Tribler et al. on TauroLock™-HEP100 in parenteral nutrition (2017)

“…In patients with intestinal failure who are life dependent on HPS, the taurolidine-citrate-heparin catheter lock demonstrates a clinically substantial and cost-beneficial reduction of CRBSI occurrence in a high-risk population compared with heparin…”

Download study by Handrup et al. on lock solutions in oncology (2013)

“…Locking of long-term tunneled CVC with taurolidine significantly reduces catheter-related bloodstream infections in children with cancer...“

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